Levetiracetam IV 60mg/kg, single dose; infuse over 15 minutes. Maximum dose 4500mg. In renal impairment: no reduction in loading dose is necessary but would have to be considered for maintenance doses once seizures are controlled (see section 2 of the GGC guideline for further details).
Administration: Give in 100ml sodium chloride 0.9% over 15 minutes. For doses greater than 3000mg, remove and discard 30mls of sodium chloride 0.9% from the bag prior to adding levetiracetam.
Please state the infusion time when prescribing on the kardex or HEPMA.
| Levetiracetam | |||
| Weight (kg) |
Dose (mg) (60mg/kg) |
Volume (ml) of 500mg/5ml injection |
|
| 35-44 | 2100 | 21 | |
| 45-54 | 2700 | 27 | |
| 55-64 | 3300 | 33 | |
| 65-74 | 3900 | 39 | |
| 75-84 | 4500 | 45 | |
| 85-95 | 4500 | 45 | |
| >95 | 4500 | 45 | |
Use of levetiracetam in status epilepticus is ‘off-label’ but is approved for use in this way within NHSGGC, an unlicensed medicine form does not need to be completed for use in this indication.
Guideline reviewed: June 2022
Page updated: September 2023
