Amikacin dosing guidelines (for patients aged ≥16 years)

For dosing and monitoring guidance see the NHSGGC Amikacin dosing guideline which includes a prescribing, administration and monitoring (PAM) chart (Appendix 1). This chart should be used for each patient and doses prescribed on HEPMA.

Amikacin sampling guidelines

• Check peaks (1 hour post-dose) and troughs (end of dosage interval) within the first 48 hours of therapy and every 2-3 days thereafter.
• Dose requirements will change if renal function alters - check creatinine concentration and eGFR daily.
• Record the exact times of all doses and samples on the request form and the sample times on the sample tubes.
• Seek advice from pharmacy or microbiology if you are unsure how to interpret the result.
• All amikacin samples are processed at the QEUH. At weekends, or outwith 9am-5pm during weekdays, individual wards may have to organise taxis themselves to QEUH biochemistry for concentration measurement. Confirm with your local biochemistry laboratory.

Guideline reviewed: June 2025

Page updated: August 2025